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Carcinogenesis, Mutagenesis, Impairment of Fertility
Studies in rats and mice suggest that azithromycin may cause an increase in cancer. For example, azithromycin has been shown to increase the proliferation of lung, uterus, ovary, breast, and prostate, as well the number of cells in colon mice. Although the exact mechanism(s) may be a subject of debate, the results indicate a potential carcinogenic risk.
In a randomized, double-blind, placebo-controlled study, rats were fed diets containing 400 ppm or 1250 azithromycin for 14 weeks. The diet contained either sodium azithromycin (sodium salt) or potassium azithromycin, and the dosage was reduced or maintained throughout the period of study. After 14 weeks exposure to the respective diets, there were generic brand for losartan significant differences in the body weights of all groups. A statistically significant difference was found between the groups (P < 0.05). In rats fed the high-dose regimen: there was an increase in tumor weight, body weights, and volume (0.04-0.06 mg/g compared with 0.02-0.02 for sodium azithromycin). In rats fed the Comprar finasteride online low-dose regimen: there was a trend towards increased tumor sizes and body weights, but there were no significant differences between the groups. In both rats, these levels of exposure were similar to those normally used in human medicine. conclusion, these results indicate that high doses of azithromycin are necessary to induce a positive response. Although the data presented in this study do not allow for a definitive conclusion about the carcinogenicity of sodium azithromycin, results from the studies Buy zaditen eye drops presented here provide foundation for further research losartan potassium tablets brands to investigate its risk for human cancer.
Although a carcinogenic risk for human exposure appears to be unlikely, these results do suggest that high doses of azithromycin (as in the study) may increase risk for tumorigenesis in rodents. The use of a lower dose would reduce the risk of tumorigenesis; however, because this is not possible, it advisable to avoid these amounts of azithromycin (at concentrations typical those commonly used in human medicine).
In summary, the data presented this review do not identify any increased risk of cancers associated with the administration of azithromycin in humans. The data provided by clinical studies of azithromycin indicate an increased incidence of a variety malignancies that are not generally recognized on the basis of known causes. Therefore, it is recommended that patients with acute or chronic infections be treated with a higher dose of azithromycin and monitored at every visits. The data in losartan 50 mg brands this review do not indicate that any of these effects is associated with any other component of azithromycin therapy. Because the data presented in this review do not establish a risk for azithromycin, the dose of azithromycin should not be modified in order to minimize the potential for increased tumor.
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